semaglutide
Semaglutide Stumbles: Tirzepatide Yields 35% Greater Weight Loss in MC4R‑Deficient Obesity, Throwing Conventional Guidelines Into Chaos
In a head-to-head analysis, tirzepatide produced 35% greater weight loss than semaglutide in patients with MC4R deficiency, even though their baseline body-mass index was lower. This surprising differential is reshaping how clinicians view GLP-1 analogs for monogenic obesity. Medical Disclaimer: This article is for informational purposes only and does not