tirzepatide lean mass

Tirzepatide linked to more lean mass loss than semaglutide — Photo by SHVETS production on Pexels

Beware Semaglutide Overdoing Your Muscle Loss

Beware Semaglutide Overdoing Your Muscle Loss Semaglutide can cause measurable lean-mass loss, especially when paired with calorie restriction, and the effect varies by dose and individual response. In the OASIS 4 trial, oral semaglutide delivered a mean weight loss of 16.6% and an unplanned lean-mass decline of 7.8%